Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists.

Dickinson A1, Smith J, Mirenowicz J.

Behav Neurosci. 2000 Jun;114(3):468-83.

PIT 在Pavlovian conditioning或/和测试期间给予DA抑制剂(pimozide and alpha-flupenthixol),使得CS+相关联的按杆次数不再升高。

??After training in which the rats performed 2 responses for different food rewards, they consumed 1 type food under the antagonists and the other type under vehicle during reexposure. When instrumental responding was subsequently tested in extinction, performance was unaffected by whether the rats had been reexposed to the training reward under the antagonists. These results suggest that Pavlovian and instrumental incentive learning are not mediated by a common process.

acute dopamine receptor antagonism over repeated incentive learning opportunities not to affect the impact of such learning on subsequent reward-seeking actions

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